Köhler Group

Dr. Simone Köhler

Simone Köhler investigates the structure and function of the synaptonemal complex in C. elegans. She is an expert in C. elegans genetics and cell biology as well as in advanced fluorescence microscopy techniques. She has determined the architecture of the synaptonemal complex in C. elegans. Her work has revealed new insight into how this structure promotes and limits the formation of crossover events to ensure the formation of healthy oocytes.

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  • Rillo-Bohn R, Adilardi R, Mitros T, Avşaroğlu B, Stevens L, Köhler S, Bayes J, Wang C, Lin S, Baskevitch KA, Rokhsar DS, Dernburg AF. Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage. Elife. 2021 Aug 24;10:e70990. doi: 10.7554/eLife.70990. PMID: 34427184; PMCID: PMC8455136.
  • Hurlock ME, Čavka I, Kursel LE, Haversat J, Wooten M, Nizami Z, Turniansky R, Hoess P, Ries J, Gall JG, Rog O, Köhler S, Kim Y. Identification of novel synaptonemal complex components in C. elegans. J Cell Biol. 2020 May 4;219(5):e201910043. doi: 10.1083/jcb.201910043. PMID: 32211899; PMCID: PMC7199856.
  • Woglar A, Yamaya K, Roelens B, Boettiger A, Köhler S, Villeneuve AM. Quantitative cytogenetics reveals molecular stoichiometry and longitudinal organization of meiotic chromosome axes and loops. PLoS Biol. 2020 Aug 19;18(8):e3000817. doi: 10.1371/journal.pbio.3000817. PMID: 32813728; PMCID: PMC7458323.
  • Zhang L, Köhler S, Rillo-Bohn R, Dernburg AF. A compartmentalized signaling network mediates crossover control in meiosis. Elife. 2018 Mar 9;7:e30789. doi: 10.7554/eLife.30789. PMID: 29521627; PMCID: PMC5906097.
  • Köhler S, Wojcik M, Xu K, Dernburg AF. Superresolution microscopy reveals the three-dimensional organization of meiotic chromosome axes in intact Caenorhabditis elegans tissue. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4734-E4743. doi: 10.1073/pnas.1702312114. Epub 2017 May 30. PMID: 28559338; PMCID: PMC5474826.
  • Rog O, Köhler S, Dernburg AF. The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors. Elife. 2017 Jan 3;6:e21455. doi: 10.7554/eLife.21455. PMID: 28045371; PMCID: PMC5268736.