Klutstein Group

Prof. Dr. Michael Klutstein

Michael Klutstein studies the molecular processes of aging in oocytes with a focus on epigenetic alterations. His lab has shown the correlation between changes in epigenetic markers, retrotransposon activation and DNA damage. He provides expertise in mouse and human ovarian tissue and oocyte culture and observing and triggering epigenetic changes.

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  • Klutstein M*PI, Moss J*s, Kaplan TPI and Cedar H PI (2017), Contribution of epigenetic mechanisms to variation in cancer risk among tissues, PNAS, 114(9):2230-2234. *equal contribution
  • Kaminski Strauss Ss, Schirman Dc, Jona Gc, Brooks ANc, Kunjapur AMc, Nguyen Ba ANc, Flint Ac, Solt Ac, Mershin Ac, Dixit Ac, Yona AHc, Csörgő Bc, Busby Bc, Hennig BPc, Pál Cc, Schraivoge Dc, Schultz Dc, Wernick DGc, Agashe Dc, Levi Dc, Zabezhinsky D, Russ D, Sass E, Tamar E, Herz E, Levy EDPI, Church GMC, Yelin IC, Nachman IC, Gerst JC, Georgeson JMC, Adamala KC, Steinmetz LMC, Rübsam MC, Ralser MC, Klutstein MC, Desai MMC, Walunjkar NC, Yin NC, Hefetz NAC, Jakimo NC, Snitser OC, Adini OC, Kumar PC, Soo Hoo Smith RC, Zeidan RC, Hazan RC, Rak RC, Kishony RC, Johnson SC, Nouriel Ss, Vonesch SCC, Foster SC, Dagan TC, Wein TC, Karydis TC, Wannier TMC, Stiles TC, Olin-Sandoval Vc, Mueller WFc, Bar-On YMPI, Dahan OPI, Pilpel Y PI, (2019), EVOLTHON: A COMMUNITY ENDEAVOR TO EVOLVE LAB EVOLUTION, PLOS Biology, 17(3):e3000182. doi: 10.1371/journal.pbio.3000182
  • Goldman Es, Reich ET, Abramovitz I PI, Klutstein M PI (2019), Inducing Apical Periodontitis in Mice, Journal of Visualized Experiments, (150). doi: 10.3791/59521
  • Aouizerat Ts, Gutman Ic, Paz Yc, Maeir AMc, Gadot Yc, Gelman Ds, Szitenberg Ac, Drori Ec, Pinkus Ac, Schoemann Ms, Kaplan Rs, Ben-Gedalya Tc, Coppenhagen-Glazer ST, Reich ET, Saragovi Ac, Lipschits Oc, Klutstein M*PI, Hazan R* PI, (*equal contribution, co-corresponding authors) (2019), Isolation and characterization of live yeast cells from ancient vessels as a tool in bio-archeology, mBio, 10(2). pii: e00388-19. doi: 10.1128/mBio.00388-19.
  • Aouizerat Ts*, Gelman Gs*, Szitenberg Ac , Gutman Ic, Glazer Sc, Reich Ec, Schoemann Ms, Kaplan Rs, Saragovi As, Hazan R PI ** and Klutstein M PI ** (*equal contribution, **co-corresponding authors) (2019), Eukaryotic adaptation to years-long starvation resembles that of bacteria, iScience, 19:545-558. doi: 10.1016/j.isci.2019.08.002
  • Aouizerat Ts, Maeir Ac, Paz Yc, Gadot Yc, Szitenberg Ac, Alkalay-Oren Ss, Coppenhagen-Glazer Sc, Klutstein M PI * and Hazan R PI * (*equal contribution, co-corresponding authors) (2019) Isolation and Characterization of Live Yeast Cells from Ancient Clay Vessels, Bio-protocol, 10(1): e3473. DOI: 10.21769/BioProtoc.3473
  • Abed Js, Maalouf Ns, Manson As, Earl As, Parhi Ls, Emgård Js, Klutstein MPI, Tayeb Ss, Almogy Gc, Atlan KAc, Chaushu SPI, Israeli EPI, Mandelboim OPI, Garrett WPI, Bachrach GPI (2020) Colon cancer-associated Fusobacterium nucleatum may originate from the oral cavity and reach colon tumors via the circulatory system, Frontiers in Cellular and Infection Microbiology, 7;10:400
  • Hou Hc, Kyriacou Ec, Thadani Rc, Klutstein MPI, Chapman JHPI, Cooper JPPI (2021), Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8, Nature, 591(7851):671-676 .
  • Goldman Es, Reich Ec, Roshihotzki Bs, Saketkhou Ms, Wald Ss, Goldstein Ac, Klein Ys, Abramovitz YPI *, Klutstein MPI * (*equal contribution, co-corresponding authors) (2021), A mouse model for studying the development of apical perio-dontitis with age, MDPI Cells, 10(3):671
  • Karavani Gc, Wasserzug-Pash Ps, Talya Mordechai-Danielc, Bauman Dc, Klutstein M PI * and Imbar T PI * (*equal contribution, co-corresponding authors) (2021), Age-dependent in-vitro maturation efficacy of Human oocytes-is there an optimal age? Frontiers in Cell and Developmental Biology, 9:667682
  • Wasserzug-Pash Ps, Rothman Rs, Reich Ec, Zecharyahu Ls, Schonberger Oc, Weiss Yc, Srebnik Nc, Cohen-Hadad Yc, Weintraub Ac, Ben-Ami Ic, Holzer Hc, Klutstein M PI(2022), Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging, Aging Cell, in press
  • Wasserzug-Pash Ps and Klutstein MPI(2019), Epigenetic changes in mammalian gametes throughout their lifetime- the four seasons metaphor, Chromosoma, 128(3):423-441. doi: 10.1007/s00412-019-00704-w.
  • Hazan RPI*, Schoemann Ms and Klutstein MPI* (2021) (*equal contribution, co-corresponding authors), Endurance of extremely-prolonged nutrient prevention across kingdoms of life, iScience, in press
  • Klutstein MPI(2021), Cause and effect in epigenetics – where lies the truth, and how can experiments reveal it? Epigenetic self-reinforcing loops obscure causation in cancer and aging, BioEssays, e2000262