Poetsch Group

Dr. Anna Poetsch

Anna Poetsch is a computational biologist studying the genomics of DNA 
damage, repair, and mutagenesis. She has developed methods to measure 
the distribution of oxidative DNA damage genome wide and developed the 
associated integrative data analysis strategies. Both DNA damage and 
resulting mutations are not distributed randomly over the genome, yet 
the underlying mechanisms are poorly understood. The group uses 
different genomics techniques, multi-omics data integration, and 
complex machine learning models to investigate the associated pathways 
and processes.
Anna provides both her wet and dry expertise in the context of genomic 
investigations on oocyte biology, including the investigation of 
genomic locations of double strand breaks under different conditions.


Link to group page:



  •  Poetsch AR*, Boulton SJ, Luscombe NM. Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis. Genome Biology. (2018) Dec. 7; 19:215. doi: 10.1186/s13059-018-1582-2.

  • Poetsch AR. The genomics of oxidative DNA damage, repair, and resulting mutagenesis. CSBJ. (2020) Jan 7;18:207-219. doi: 10.1016/j.csbj.2019.12.013.

  • Poetsch AR. AP-seq, a method to detect apurinic sites and modified bases genome wide. Methods Mol Biol. (2020) ;2175:95-108.doi: 10.1007/978-1-0716-0763-3_8

  • Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Goldstone R, Poetsch AR, Boulton SJ. RTEL1 Regulates G4/R-Loops to Avert Replication- Transcription Collisions. Cell Reports. (2020) Dec; 33: 108546. doi: 10.1016/j.celrep.2020.108546.

  • Chakrabarti AM, Henser-Brownhill T, Monserrat J, Poetsch AR*, Luscombe NM, Scaffidi P*. Target-specific predictability of CRISPR-mediated genome editing. Molecular Cell. (2019) Feb. 21; 73:1–15. doi: 10.1016/j.molcel.2018.11.031.