Poetsch Group
Dr. Anna Poetsch
Anna Poetsch is a computational biologist studying the genomics of DNA
damage, repair, and mutagenesis. She has developed methods to measure
the distribution of oxidative DNA damage genome wide and developed the
associated integrative data analysis strategies. Both DNA damage and
resulting mutations are not distributed randomly over the genome, yet
the underlying mechanisms are poorly understood. The group uses
different genomics techniques, multi-omics data integration, and
complex machine learning models to investigate the associated pathways
and processes.
Anna provides both her wet and dry expertise in the context of genomic
investigations on oocyte biology, including the investigation of
genomic locations of double strand breaks under different conditions.
Link to group page:
Publications
Poetsch AR*, Boulton SJ, Luscombe NM. Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis. Genome Biology. (2018) Dec. 7; 19:215. doi: 10.1186/s13059-018-1582-2.
Poetsch AR. The genomics of oxidative DNA damage, repair, and resulting mutagenesis. CSBJ. (2020) Jan 7;18:207-219. doi: 10.1016/j.csbj.2019.12.013.
Poetsch AR. AP-seq, a method to detect apurinic sites and modified bases genome wide. Methods Mol Biol. (2020) ;2175:95-108.doi: 10.1007/978-1-0716-0763-3_8
Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Goldstone R, Poetsch AR, Boulton SJ. RTEL1 Regulates G4/R-Loops to Avert Replication- Transcription Collisions. Cell Reports. (2020) Dec; 33: 108546. doi: 10.1016/j.celrep.2020.108546.
Chakrabarti AM, Henser-Brownhill T, Monserrat J, Poetsch AR*, Luscombe NM, Scaffidi P*. Target-specific predictability of CRISPR-mediated genome editing. Molecular Cell. (2019) Feb. 21; 73:1–15. doi: 10.1016/j.molcel.2018.11.031.